Pharmaceutical Chemistry Group

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About Us

Understanding how molecules find a unique binding position on a segment of DNA ranks among the most fascinating and important current chemical and/or biochemical questions because it is absolutely essential for determining how biological systems work. The rational therapeutic drug design clearly requires an understanding of the physical and chemical principles involved in DNA and RNA recognition and would use this information. The rational design of such binding molecules clearly requires an understanding of the physical and chemical principles involved in DNA and RNA recognition.

Our objective is to significantly extend our understanding of the principles involved in sequence-specific recognition of biological molecules like DNA by carrying out investigations of the binding of metal complexes. The result of this work has far-reaching consequences on the rational design of DNA-based chemotherapeutic agents, effective DNA probes and DNA-sequencing agents.

To achieve our objectives we endeavour to understand how DNA discriminates between the metal complexes through the design, synthesis, resolution, characterisation, binding affinity determination and biological activity of novel metal complexes.